Popular Daphne Blake and über-nerd Velma Dinkley are not friends. They aren't enemies either, but they don't have any reason to speak to each other and that's how they prefer it. The two girls grew up together – they'd been best friends since pre-school – but when they hit middle school, Daphne dropped Velma and never looked back.
These days, Daphne's deep in the popular crowd, daughter of the richest family in town, while Velma's an outsider, hiding from the world behind her thick glasses. When they run into each other in the halls of Crystal Cove High, they look the other way. But then Daphne's best friend, Marcy – who happens to be Velma's cousin – goes missing.